SBI-4668 | SHP2 inhibitor | Probechem Biochemicals

Chemical Structure : SBI-4668

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SBI-4668 (SBI-668, SBI 4668)

货号: PC-38184Not For Human Use, Lab Use Only.

SBI-4668 (SBI-668) is a novel furanylbenzamide molecule inhibitor of both WT and oncogenic SHP2 with IC50 of 0.73/1.8 uM for Wt SHP2/SHP2-E76K, 13-fold selective over PTP1B and 73-fold selective over STEP.

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生物&药学活性

SBI-4668 (SBI-668) is a novel furanylbenzamide molecule inhibitor of both WT and oncogenic SHP2 with IC50 of 0.73/1.8 uM for Wt SHP2/SHP2-E76K, 13-fold selective over PTP1B and 73-fold selective over STEP.
SBI-4668 exhibited cell viability inhibitory effect on cell growth in both Kasumi-1 cells (IC50=8.5 uM) and KYSE-520 cells (IC50=5.4 uM), SBI-4668 on cell viability was also determined in additional AML cell lines, including MOLM-13 (IC50 = 12 μM) and MV4-11 (IC50 = 8.2 μM).
SBI-4668 inhibited U-937 cell (harbor a G60R oncogenic mutation in SHP2) growth with IC50 of 6.3 uM, which is comparable to the potency found in AML cells expressing WT SHP2, while RMC4550 showed a very weak effect on this G60R mutation cell.

物理化学性质&存储条件

分子量	439.485
分子式	C26H17NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 1 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-2-hydroxy-5-(5-((3-oxobenzo[b]thiophen-2(3H)-ylidene)methyl)furan-2-yl)-N-phenylbenzamide

参考文献

1. Raveendra-Panickar D, et al. J Biol Chem. 2022 Jan;298(1):101477.

SBI-4668 (SBI-668, SBI 4668)

生物&药学活性

物理化学性质&存储条件

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SBI-4668 (SBI-668, SBI 4668)

生物&药学活性

物理化学性质&存储条件

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