SBI-425 |CAS:1451272-71-1 Probechem Biochemicals

Chemical Structure : SBI-425

CAS No.: 1451272-71-1

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SBI-425 (SBI425, SBI 425)

货号: PC-62544Not For Human Use, Lab Use Only.

SBI-425 (SBI425) is a potent, selective, orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 16 nM, shows high selectivity over other alkaline phosphatases including IAP and PLAP.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3680	In stock
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100 mg		Get quote

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生物&药学活性

SBI-425 (SBI425) is a potent, selective, orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor with IC50 of 16 nM.
SBI-425 shows high selectivity over other alkaline phosphatases including IAP and PLAP.
SBI-425 demonstrates activity in blocking calcification in patient derived fibroblasts as well as in rodent models of GACI and PXE.
SBI-425 reduces coronary calcium and lipids, improves body weight and ejection fraction in WHC-eTNAP mice.

物理化学性质&存储条件

分子量	341.766
分子式	C13H12ClN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide

参考文献

1. Pinkerton AB, et al. Bioorg Med Chem Lett. 2018 Jan 1;28(1):31-34.

2. Romanelli F, et al. PLoS One. 2017 Oct 12;12(10):e0186426.

3. Sheen CR, et al. J Bone Miner Res. 2015 May;30(5):824-36.

SBI-425 (SBI425, SBI 425)

生物&药学活性

物理化学性质&存储条件

参考文献

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SBI-425 (SBI425, SBI 425)

生物&药学活性

物理化学性质&存储条件

参考文献

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