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首页-小分子抑制剂&激动剂-Others-Amyloids-SBI-2771
SBI-2771

Chemical Structure : SBI-2771

CAS No.: 354536-59-7

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SBI-2771

货号: PC-28529Not For Human Use, Lab Use Only.

SBI-2771 is a small-molecule inhibitor of the Tau-LRP1 (low-density lipoprotein receptor-related protein 1) interaction with IC50 of 4.5 uM in LRP1-BD4-L57 TR-FRET assay, reduces tau uptake in H4 neuroglioma cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SBI-2771 is a small-molecule inhibitor of the Tau-LRP1 (low-density lipoprotein receptor-related protein 1) interaction with IC50 of 4.5 uM in LRP1-BD4-L57 TR-FRET assay, reduces tau uptake in H4 neuroglioma cells.

物理化学性质&存储条件

分子量 390.13
分子式 C11H5Cl2F4N3O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3,4-dichlorophenyl)-3-(5-fluoro-4-oxo-5-(trifluoromethyl)-4,5-dihydrothiazol-2-yl)urea

参考文献

1. Wang C, et al. ACS Chem Biol. 2026 Oct 13. doi: 10.1021/acschembio.6c00599.

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