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首页-小分子抑制剂&激动剂-Others-Other Targets-SBI-183
SBI-183

Chemical Structure : SBI-183

CAS No.: 625403-59-0

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SBI-183 (SBI 183)

货号: PC-38165Not For Human Use, Lab Use Only.

SBI-183 is a small molecule that binds to and inhibits the enzymatic activity of Quiescin sulfhydryl oxidase 1 (QSOX1, Kd=20 uM).

规格 价格 库存 数量
5 mg ￥1880 In stock
10 mg ￥2880 In stock
25 mg ￥4580 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SBI-183 is a small molecule that binds to and inhibits the enzymatic activity of Quiescin sulfhydryl oxidase 1 (QSOX1, Kd=20 uM).
SBI-183 inhibits proliferation of tumor cells, but does not kill fibroblasts or rapidly proliferating PBMC, inhibits viability of 786-O, RCJ-41T2, and MDA-MB-231 with IC50 of 4.6 μM, 3.9 μM, and 2.4 μM respectively.
Oral administration of SBI-183 inhibits tumor growth in 2 independent human xenograft mouse models of renal cell carcinoma.

物理化学性质&存储条件

分子量 296.37
分子式 C18H20N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-methoxy-N-[4-(1-pyrrolidinyl)phenyl]benzamide

参考文献

1. Paul D Hanavan, et al. Oncotarget. 2015 Jul 30;6(21):18418-28.

2. Amber L Fifield, et al. Mol Cancer Ther. 2020 Jan;19(1):112-122.

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