SBI-0498 | eIF4F inhibitor | Probechem Biochemicals

Chemical Structure : SBI-0498

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SBI-0498 (SBI-0730498, SBI 0498)

货号: PC-20686Not For Human Use, Lab Use Only.

SBI-0498 (SBI-0730498) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels.

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生物&药学活性

SBI-0498 (SBI-0730498) is a small molecule inhibitor of coronaviruses translation initiation complex 4F (eIF4F), disrupts eIF4F complex formation and inhibits coronavirus RNA and protein levels.
SBI-0498 inhibits human coronavirus OC43 (HCoV-OC43; OC43) with minimal cell toxicity.
SBI-0498 (0-10 uM) is more potent than remdesivir (Cat# PC-60313) in decreasing the proportion of infected cells when assessed 48 h post treatment, significantly reduces viral RNA levels.
SBI-0498 can dissociate mRNAs from the eIF4F complex.
SBI-0498 reverses gene expression signatures induced upon HCoV-OC43 infection.

物理化学性质&存储条件

分子量	355.86
分子式	C21H22ClNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-(3-(2-chlorophenoxy)propyl)-7-ethyl-1H-indol-3-yl)ethan-1-one

参考文献

1. Yongmei Feng, et al. Front Pharmacol. 2022 Dec 1;13:1029093.

SBI-0498 (SBI-0730498, SBI 0498)

生物&药学活性

物理化学性质&存储条件

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SBI-0498 (SBI-0730498, SBI 0498)

生物&药学活性

物理化学性质&存储条件

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