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首页-小分子抑制剂&激动剂-Autophagy-ULK-SBI-0206965
SBI-0206965

Chemical Structure : SBI-0206965

CAS No.: 1884220-36-3

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SBI-0206965 (SBI 0206965;SBI0206965)

货号: PC-45106Not For Human Use, Lab Use Only.

SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM.

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1780 In stock
25 mg ￥2880 In stock
50 mg ￥4780 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SBI-0206965 (SBI 0206965) is a potent and specific small molecule ULK1 kinase inhibitor with IC50 of 108 nM.
SBI-0206965 displays 7-fold less potency for ULK2 (IC50=711 nM).
SBI-0206965 inhibits Beclin1 Ser15 and Vps34 Ser249 phosphorylation to comparable extents in HEK-293T cells。
SBI-0206965 suppresses autophagy induced by mTOR inhibition and prevents ULK1-dependent cell survival。
SBI-0206965 greatly synergizes with mTOR inhibitors to kill tumor cells.

物理化学性质&存储条件

分子量 489.3192
分子式 C21H21BrN4O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((5-bromo-2-((3,4,5-trimethoxyphenyl)amino)pyrimidin-4-yl)oxy)-N-methylbenzamide

参考文献

1. Egan DF, et al. Mol Cell. 2015 Jul 16;59(2):285-97.

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