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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Complement System-SB290157
SB290157

Chemical Structure : SB290157

CAS No.: 259218-28-5

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SB290157 (SB-290157, SB 290157)

货号: PC-60789Not For Human Use, Lab Use Only.

SB290157 (SB 290157) is a potent, selective nonpeptide antagonist of anaphylatoxin C3a receptor (C3aR) with IC50 of 200 nM.

规格 价格 库存 数量
5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1380 In stock
50 mg ￥2180 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SB290157 (SB 290157) is a potent, selective nonpeptide antagonist of anaphylatoxin C3a receptor (C3aR) with IC50 of 200 nM.
SB290157 does not antagonize the C5aR or 5 other chemotactic GPCRs on human neutrophils.
SB290157 blocks C3a-induced C3aR internalization and C3a-induced Ca(2+) mobilization in RBL-C3aR cells and human neutrophils with IC50 of 27.7 and 28 nM, respectively.
SB290157 also inhibits C3a-induced Ca2+ mobilization of mouse and guinea pig C3aRS with IC50 of 7 and 12.5 nM, respectively.
SB290157 potently inhibits C3a-mediated ATP release from guinea pig platelets and inhibits C3a-induced potentiation of the contractile response to field stimulation of perfused rat caudal artery, demonstrates antiinflammatory activity in animal models.

物理化学性质&存储条件

分子量 412.49
分子式 C22H28N4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N(2)-[(2,2-diphenylethoxy)acetyl]-L-arginine

参考文献

1. Ames RS, et al. J Immunol. 2001 May 15;166(10):6341-8.

2. Therien AG. J Immunol. 2005 Jun 15;174(12):7479; author reply 7479-80.

3. Ratajczak J, et al. Blood. 2004 Mar 15;103(6):2071-8.

4. Proctor LM, et al. Br J Pharmacol. 2004 Jun;142(4):756-64.

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