SB27012 | Spike RBD-ACE2 inhibitor | Probechem Biochemicals

Chemical Structure : SB27012

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SB27012 (SB 27012)

货号: PC-38235Not For Human Use, Lab Use Only.

SB27012 (SB 27012) is a small molecule PPI inhibitor of the Spike RBD-ACE2 interaction (IC50=7.7 uM in ELISA assays), binds ACE2 (Kd=210 nM) without affecting ACE2 enzymatic activity.

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生物&药学活性

SB27012 (SB 27012) is a small molecule PPI inhibitor of the Spike RBD-ACE2 interaction (IC50=7.7 uM in ELISA assays), binds ACE2 (Kd=210 nM) without affecting ACE2 enzymatic activity.
Using a sandwich ELISA-based screening using the plate-bound RBD (Arg319-Phe541) and extracellular domain of human ACE2 (Gln18-Ser740), SB27012 was identified and affinity determinated.
SB27012 inhibits the ACE2-spike interaction by inducing allosteric changes in ACE2.
SB27012 blocked the SARS-CoV-2 spread with IC50 of 3.3 uM.
SB27012 reduced infection predominantly at early time points, suggesting that SB27012 blocked the entry step of viral infection.

物理化学性质&存储条件

分子量	602.739
分子式	C36H38N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	benzyl (6aS,9aS)-10-benzyl-4-(benzyl(methyl)amino)-8-(cyclopropanecarbonyl)-6a,7,8,9,9a,10-hexahydropyrimido[4,5-e]pyrrolo[3,4-b][1,4]diazepine-6(5H)-carboxylate

参考文献

1. Young-Hee Shin, et al. Angew Chem Int Ed Engl. 2022 Jan 18;e202115695.

SB27012 (SB 27012)

生物&药学活性

物理化学性质&存储条件

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SB27012 (SB 27012)

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物理化学性质&存储条件

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