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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-SB269970
SB269970

Chemical Structure : SB269970

CAS No.: 201038-74-6

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SB269970 (SB-269970)

货号: PC-22277Not For Human Use, Lab Use Only.

SB269970 (SB-269970) is a potent, selective 5-HT7 receptor antagonist with pKi of 8.9, >100-fold selective over other 5-HT receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SB269970 (SB-269970) is a potent, selective 5-HT7 receptor antagonist with pKi of 8.9, >100-fold selective over other 5-HT receptors.
SB-269970 (0.03-1 microM) inhibited the 5-CT concentration-response with no significant alteration in the maximal response.

物理化学性质&存储条件

分子量 352.49
分子式 C18H28N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol

参考文献

1. Roberts C, et al. Br J Pharmacol. 2001 Apr;132(7):1574-80.

2. Hagan JJ, et al. Br J Pharmacol. 2000 Jun;130(3):539-48.

3. Lovell PJ, et al. J Med Chem. 2000 Feb 10;43(3):342-5.

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