SB 242084 | 5-HT2C antagonist | Probechem Biochemicals

Chemical Structure : SB 242084

CAS No.: 181632-25-7

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SB 242084 (SB-242084, SB242084)

货号: PC-43515Not For Human Use, Lab Use Only.

SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist with pKi of 9.0, 100- and 158-fold selectivity over the closely related 5-HT2B and 5-HT2A subtypes.

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

SB 242084 is a potent, selective, brain penetrant 5-HT2C receptor antagonist with pKi of 9.0, 100- and 158-fold selectivity over the closely related 5-HT2B and 5-HT2A subtypes.
SB 242084 also displays >100-fold selectivity over a range of other 5-HT, dopamine and adrenergic receptors.
SB 242084 inhibits 5-HT-stimulated phosphatidylinositol hydrolysis with pKb of 9.3 in cell-baed assays.
SB 242084 potently inhibits m-chlorophenylpiperazine (mCPP)-induced hypolocomotion in rats, with an ID50 of 0.11 mg/kg i.p., and 2.0 mg/kg p.o.

物理化学性质&存储条件

分子量	394.86
分子式	C21H19ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 44 mg/mL
Chemical Name/SMILES	1H-Indole-1-carboxamide, 6-chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-

参考文献

1. Bromidge SM, et al. J Med Chem. 1997 Oct 24;40(22):3494-6.

2. Kennett GA, et al. Neuropharmacology. 1997 Apr-May;36(4-5):609-20.

3. Di Matteo V, et al. Neuropharmacology. 1999 Aug;38(8):1195-205.

SB 242084 (SB-242084, SB242084)

生物&药学活性

物理化学性质&存储条件

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SB 242084 (SB-242084, SB242084)

生物&药学活性

物理化学性质&存储条件

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