SB 239063 | p38 MAPK inhibitor | Probechem Biochemicals

Chemical Structure : SB 239063

CAS No.: 193551-21-2

加入收藏

SB 239063 (SB-239063, SB239063)

货号: PC-42803Not For Human Use, Lab Use Only.

SB 239063 is a potent, selective, orally available p38 MAPK inhibitor with IC50 of 44 nM for both p38α and p38β.

规格	价格	库存
1 mg (Free Sample)	￥280	In stock
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SB 239063 is a potent, selective, orally available p38 MAPK inhibitor with IC50 of 44 nM for both p38α and p38β.
SB 239063 shows no activity (>100 μM) against the γ- and δ-kinase isoforms, and a panel of protein kinase.
SB 239063 inhibits IL-1 and TNF-alpha production in LPS-stimulated human PBMCs (IC50= 0.12 and 0.35 uM).
SB 239063 reduces inflammatory cytokine production, airways eosinophil infiltration and persistence in vivo.

物理化学性质&存储条件

分子量	368.4048
分子式	C20H21FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cyclohexanol, 4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-, trans-

参考文献

1. Underwood DC, et al. J Pharmacol Exp Ther. 2000 Apr;293(1):281-8.

2. Underwood DC, et al. Am J Physiol Lung Cell Mol Physiol. 2000 Nov;279(5):L895-902.

3. Barone FC, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):312-21.

4. Legos JJ, et al. Brain Res. 2001 Feb 16;892(1):70-7.

SB 239063 (SB-239063, SB239063)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SB 239063 (SB-239063, SB239063)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.