SB 224289 hydrochloride | 5-HT1B antagonist | Probechem Biochemicals

Chemical Structure : SB 224289 hydrochloride

CAS No.: 180084-26-8

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SB 224289 hydrochloride (SB-224289)

货号: PC-38596Not For Human Use, Lab Use Only.

SB 224289 hydrochloride is a potent, selective 5-HT1B inverse agonist/antagonist with pKi value of 8.16, displays >75-fold selectivity over all other 5-HT receptors.

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生物&药学活性

SB 224289 hydrochloride is a potent, selective 5-HT1B inverse agonist/antagonist with pKi value of 8.16, displays >75-fold selectivity over all other 5-HT receptors.
SB 224289 is a potent antagonist of terminal 5-HT autoreceptor function both in vitro and in vivo.

物理化学性质&存储条件

分子量	557.091
分子式	C32H33ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methanone, [2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1′-biphenyl]-4-yl](2,5,6,7-tetrahydro-1′-methylspiro[3H-furo[2,3-f]indole-3,4′-piperidin]-5-yl)-, hydrochloride (1:1)

参考文献

1. Gaster LM, et al. J Med Chem. 1998 Apr 9;41(8):1218-35.

2. Pauwels PJ, et al. Br J Pharmacol. 1998 Jan;123(1):51-62.

3. Verheggen R, et al. Br J Pharmacol. 1998 Aug;124(7):1345-54.

4. J V Selkirk, et al. Br J Pharmacol. 1998 Sep;125(1):202-8.

SB 224289 hydrochloride (SB-224289)

生物&药学活性

物理化学性质&存储条件

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SB 224289 hydrochloride (SB-224289)

生物&药学活性

物理化学性质&存储条件

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