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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-ATP Citrate Lyase (ACL, ACLY) -SB204990
SB204990

Chemical Structure : SB204990

CAS No.: 154566-12-8

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SB204990 (SB 204990, SB-204990)

货号: PC-62188Not For Human Use, Lab Use Only.

SB204990 is the cell-penetrant, orally active gamma-lactone prodrug of the potent ATP citrate-lyase (ACLY) inhibitor SB-201076.

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3280 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SB204990 is the cell-penetrant, orally active gamma-lactone prodrug of the potent ATP citrate-lyase (ACLY) inhibitor SB-201076.
SB204990 inhibits cholesterol and fatty acid synthesis in HepG2 cells and reduces plasma triglyceride levels in vivo.
SB204990 induces clear hypocholesterolemic and hypotriglyceridaemic responses in rats.

物理化学性质&存储条件

分子量 389.27
分子式 C18H22Cl2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

参考文献

1. Pearce NJ, et al. Biochem J. 1998 Aug 15;334 ( Pt 1):113-9.

2. Bracha AL, et al. Nat Chem Biol. 2010 Mar;6(3):202-204.

3. Hatzivassiliou G, et al. Cancer Cell. 2005 Oct;8(4):311-21.

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