SB203580 | p38 MAPK inhibitor | Probechem Biochemicals

Chemical Structure : SB203580

CAS No.: 152121-47-6

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SB203580 (Adezmapimod, RWJ 64809;SB 203580, SB-203580)

货号: PC-42491Not For Human Use, Lab Use Only.

SB203580 (Adezmapimod, RWJ 64809) is a specific p38 MAPK inhibitor with IC50 of 0.6 uM.

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5 mg (Free Sample)	￥280	In stock
25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg		Get quote

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生物&药学活性

SB203580 (Adezmapimod, RWJ 64809) is a specific p38 MAPK inhibitor with IC50 of 0.6 uM.
SB 203580 shows selectivity over JNK, p42 MAPK, p90 S6K, p70 S6K, PKA, etc..
SB 203580 suppresses the activation of MAPKAP kinase-2 and prevents the phosphorylation of HSP27 in response to interleukin-1, cellular stresses and bacterial endotoxin in vivo.

物理化学性质&存储条件

分子量	377.4346
分子式	C21H16FN3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]-

参考文献

1. Cuenda A, et al. FEBS Lett. 1995 May 8;364(2):229-33.

2. Lali FV, et al. J Biol Chem. 2000 Mar 10;275(10):7395-402.

3. Badger AM, et al. J Pharmacol Exp Ther. 1996 Dec;279(3):1453-61.

SB203580 (Adezmapimod, RWJ 64809;SB 203580, SB-203580)

生物&药学活性

物理化学性质&存储条件

参考文献

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SB203580 (Adezmapimod, RWJ 64809;SB 203580, SB-203580)

生物&药学活性

物理化学性质&存储条件

参考文献

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