SB1501 | CAS 2757411-32-6 | Probechem Biochemicals

Chemical Structure : SB1501

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SB1501 (SB 1501)

货号: PC-20138Not For Human Use, Lab Use Only.

SB1501 (SB 1501) is a bioactive compound that reduces fat accumulation by elevating mitochondrial biogenesis and fatty acid oxidation via the PGC-1α-UCP1 pathway, shows anti-obesity effects in vivo.

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生物&药学活性

SB1501 (SB 1501) is a bioactive compound that reduces fat accumulation by elevating mitochondrial biogenesis and fatty acid oxidation via the PGC-1α-UCP1 pathway, shows anti-obesity effects in vivo.
SB1501 (40 μM) reduces the size and fat accumulation of lipid droplets (LDs) in 3T3-L1 adipocytes.
SB1501 increases mitochondrial biogenesis and fatty acid oxidation (FAO) with upregulation of PGC-1α-UCP1 regulatory axis, which leads to reduced fat accumulation and demand for lipid storage capacity in 3T3-L1 adipocyte.
SB1501 increases mitochondrial function and morphology in 3T3-L1 adipocytes.
SB1501 (10 mg/kg, 5 weeks, oral) exhibits anti-obesity effects in a db/db mouse model.
SB1501 significantly increased the mRNA levels of Pgc-1α and Ucp1 in inguinal white adipose tissue.

物理化学性质&存储条件

分子量	349.39
分子式	C20H19N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-(2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)-2,2-dimethyl-2H-chromen-7-ol

参考文献

1. Jo A, et al. ChemMedChem. 2021 Apr 8;16(7):1104-1115.

SB1501 (SB 1501)

生物&药学活性

物理化学性质&存储条件

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SB1501 (SB 1501)

生物&药学活性

物理化学性质&存储条件

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