SB1-F-70 |CAS:1895050-95-9 Probechem Biochemicals

Chemical Structure : SB1-F-70

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SB1-F-70

货号: PC-38155Not For Human Use, Lab Use Only.

SB1-F-70 is a potent, selective inhibitor of the deubiquitinase (DUB) JOSD1/USP30/UCHL1 with IC50 of 324/400/400 nM, respectively.

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生物&药学活性

SB1-F-70 is a potent, selective inhibitor of the deubiquitinase (DUB) JOSD1/USP30/UCHL1 with IC50 of 324/400/400 nM, respectively.
SB1-F-70 displays selectivity against a panel of 41 purified DUB enzymes.
SB1-F-70 selectively degraded JAK2-V617F and kill JAK2-V617F-expressing Ba/F3 cells, SB1-F-70 selectively degrades JAK2-V617F in human AML cells, promotes ubiquitin-mediated proteasomal degradation of JAK2-V617F.
Targeting of JOSD1 via SB1-F-70 leads to the death of JAK2-V617F-positive primary acute myeloid leukemia (AML) cells.

物理化学性质&存储条件

分子量	367.427
分子式	C18H17N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-cyano-N-(6-(3,5-dimethylisoxazol-4-yl)benzo[d]thiazol-2-yl)pyrrolidine-3-carboxamide

参考文献

1. Jing Yang, et al. Leukemia. 2022 Jan;36(1):210-220.

SB1-F-70

生物&药学活性

物理化学性质&存储条件

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SB1-F-70

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物理化学性质&存储条件

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