SB-743921 |CAS:940929-33-9 Probechem Biochemicals

Chemical Structure : SB-743921

CAS No.: 940929-33-9

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SB-743921 (SB743921;SB 743921)

货号: PC-42882Not For Human Use, Lab Use Only.

SB-743921 (SB-743921) is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, shows no activity against MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.

规格	价格	库存
1 mg (Free Sample)	￥280	In stock
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2680	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SB-743921 (SB-743921) is a potent, selective kinesin spindle protein (KSP) inhibitor with Ki of 0.1 nM, shows no activity against MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E.
SB-743921 also shows high affinity for mouse KSP with Ki of 0.12 nM.
SB-743921 blocks assembly of a functional mitotic spindle, thereby causing cell cycle arrest in mitosis and subsequent cell death in cancer cells, demonstrates improved potency over ispinesib in both biochemical and cellular assays.
SB-743921 shows a broad spectrum of tumor inhibition in multiple cancer models.

物理化学性质&存储条件

分子量	553.5193
分子式	C31H34Cl2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzamide, N-(3-aminopropyl)-N-[(1R)-1-[7-chloro-4-oxo-3-(phenylmethyl)-4H-1-benzopyran-2-yl]-2-methylpropyl]-4-methyl-, hydrochloride (1:1)

参考文献

1. Good JA, et al. J Med Chem. 2013 Mar 14;56(5):1878-93.

2. Holen KD, et al. Cancer Chemother Pharmacol. 2011 Feb;67(2):447-54.

3. Zhu L, et al. Anticancer Drugs. 2016 Oct;27(9):863-72.

4. Talapatra SK, et al. J Med Chem. 2013 Aug 22;56(16):6317-29.

SB-743921 (SB743921;SB 743921)

生物&药学活性

物理化学性质&存储条件

参考文献

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SB-743921 (SB743921;SB 743921)

生物&药学活性

物理化学性质&存储条件

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