SB-705498 |CAS:501951-42-4 Probechem Biochemicals

Chemical Structure : SB-705498

CAS No.: 501951-42-4

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SB-705498 (SB 705498;SB705498)

货号: PC-42688Not For Human Use, Lab Use Only.

SB-705498 (SB705498) is a potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).

规格	价格	库存
5 mg (Free Sample)	￥180	In stock
10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

SB-705498 (SB705498) is a potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).
SB-705498 causes rapid and reversible inhibition of the capsaicin (IC50=3 nM), acid (pH 5.3), or heat (50 degrees C; IC50=6 nM)-mediated activation of human TRPV1 (at -70 mV).

物理化学性质&存储条件

分子量	429.2343
分子式	C17H16BrF3N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-(2-bromophenyl)-N'-[(3R)-1-[5-(trifluoromethyl)-2-pyridinyl]-3-pyrrolidinyl]-

参考文献

1. Rami HK, et al. Bioorg Med Chem Lett. 2006 Jun 15;16(12):3287-91.

2. Gunthorpe MJ, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1183-92.

3. Chizh BA, et al. Pain. 2007 Nov;132(1-2):132-41.

SB-705498 (SB 705498;SB705498)

生物&药学活性

物理化学性质&存储条件

参考文献

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SB-705498 (SB 705498;SB705498)

生物&药学活性

物理化学性质&存储条件

参考文献

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