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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-SB-699551
SB-699551

Chemical Structure : SB-699551

CAS No.: 791789-61-2

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SB-699551 (SB699551)

货号: PC-38716Not For Human Use, Lab Use Only.

SB699551 is a potent, selective 5-HT5A receptor antagonist with pKi of 8.3, >100-fold selectivity over 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors.

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10 mg ￥2980 In stock
25 mg ￥5280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SB699551 is a potent, selective 5-HT5A receptor antagonist with pKi of 8.3, >100-fold selectivity over 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors.
SB699551 also is a novel PSMD4/Rpn10 inhibitor, decreases cell viability in MM cell lines.

物理化学性质&存储条件

分子量 511.754
分子式 C34H45N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[2-(Dimethylamino)ethyl]-N-[[4'-[[(2-phenylethyl)amino]methyl][1,1'-biphenyl]-4-yl]methyl]cyclopentanepropanamide

参考文献

1. Thomas DR, et al. Neuropharmacology. 2006 Sep;51(3):566-77.

2. Du T, et al. Blood. 2023 Jan 11:blood.2022017897.

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