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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-SB-699551
SB-699551

Chemical Structure : SB-699551

CAS No.: 864741-95-7

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SB-699551 (SB699551)

货号: PC-38716Not For Human Use, Lab Use Only.

SB-699551 is a potent, selective 5-HT5A receptor antagonist with pKi of 8.3, >100-fold selectivity over 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors.

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5 mg ￥980 In stock
10 mg ￥1580 In stock
25 mg ￥2780 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SB-699551 is a potent, selective 5-HT5A receptor antagonist with pKi of 8.3, >100-fold selectivity over 5-HT1B/D, 5-HT2A, 5-HT2C, 5-HT1A and 5-HT7 receptors.
SB-699551 also is a novel PSMD4/Rpn10 inhibitor, decreases cell viability in MM cell lines.

物理化学性质&存储条件

分子量 584.67
分子式 C34H47Cl2N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-Cyclopentyl-N-(2-(dimethylamino)ethyl)-N-((4'-((phenethylamino)methyl)-[1,1'-biphenyl]-4-yl)methyl)propanamide dihydrochloride

参考文献

1. Thomas DR, et al. Neuropharmacology. 2006 Sep;51(3):566-77.

2. Du T, et al. Blood. 2023 Jan 11:blood.2022017897.

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