SB-612111 hydrochloride | NOP receptor antagonist | Probechem Biochemicals

Chemical Structure : SB-612111 hydrochloride

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SB-612111 hydrochloride (SB 612111, SB612111)

货号: PC-60800Not For Human Use, Lab Use Only.

SB-612111 hydrochloride is a potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM.

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生物&药学活性

SB-612111 hydrochloride is a potent, selective opiate receptor-like orphan receptor (ORL-1, NOP) antagonist with Ki of 0.33 nM.
SB-612111 displays good selectivity versus mu-(174-fold), delta-(6391-fold), and kappa (486-fold)-opioid receptors.
SB-612111 antagonizes the antimorphine action of nociceptin (ED50= 0.69 mg/kg) with no measurable antinociceptive effects in vivo.
SB-612111 antagonizes nociceptin-induced thermal hyperalgesia (ED50=0.62 mg/kg i.v.) in rat carrageenan inflammatory pain model.

物理化学性质&存储条件

分子量	454.86
分子式	C24H29Cl2NO.HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-[[4-(2,6-Dichlorophenyl)-1-piperidinyl]methyl]-6,7,8,9-tetrahydro-1-methyl-5H-benzocyclohepten-5-ol hydrochloride

参考文献

1. Liao YY, et al. Eur J Pharmacol. 2011 Apr 25;657(1-3):84-8.

2. Spagnolo B, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):961-7.

3. Rizzi A, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):968-74.

4. Zaratin PF, et al. J Pharmacol Exp Ther. 2004 Feb;308(2):454-61.

SB-612111 hydrochloride (SB 612111, SB612111)

生物&药学活性

物理化学性质&存储条件

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SB-612111 hydrochloride (SB 612111, SB612111)

生物&药学活性

物理化学性质&存储条件

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