SB-525334 | ALK5 inhibitor | Probechem Biochemicals

Chemical Structure : SB-525334

CAS No.: 356559-20-1

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SB-525334 (SB 525334, SB525334)

货号: PC-42858Not For Human Use, Lab Use Only.

SB-525334 is a potent and selective inhibitor of TGF-β1 receptor (ALK5) inhibitor with IC50 of 14,5 nM, 4-fold less potent against ALK4 and inactive for ALK2, ALK3, and ALK6 (IC50>10 uM).

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

SB-525334 is a potent and selective inhibitor of TGF-β1 receptor (ALK5) inhibitor with IC50 of 14,5 nM, 4-fold less potent against ALK4 and inactive for ALK2, ALK3, and ALK6 (IC50>10 uM).
SB 525334 blocks TGFβ1-induced phosphorylation and nuclear translocation of Smad2/3 in renal proximal tubule cells and inhibits TGFβ1-induced increases in PAI-1 and procollagen α1 mRNA expression in A498 renal epithelial carcinoma cells at 1 uM.
SB 525334 significantly inhibits PAN-induced proteinuria in rat model of nephritis-induced renal fibrosis.

物理化学性质&存储条件

分子量	343.4249
分子式	C21H21N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 46 mg/mL
Chemical Name/SMILES	Quinoxaline, 6-[2-(1,1-dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]-

参考文献

1. Grygielko ET, et al. J Pharmacol Exp Ther. 2005 Jun;313(3):943-51.

2. Laping NJ, et al. Clin Cancer Res. 2007 May 15;13(10):3087-99.

3. Thomas M, et al. Am J Pathol. 2009 Feb;174(2):380-9.

4. Kim YJ, et al. Anticancer Res. 2012 Mar;32(3):799-806.

SB-525334 (SB 525334, SB525334)

生物&药学活性

物理化学性质&存储条件

参考文献

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SB-525334 (SB 525334, SB525334)

生物&药学活性

物理化学性质&存储条件

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