SB-435495 |CAS:304694-39-1 Probechem Biochemicals

Chemical Structure : SB-435495

CAS No.: 304694-39-1

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SB-435495 (SB435495)

货号: PC-63003Not For Human Use, Lab Use Only.

SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM.

规格	价格	库存
5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3680	In stock
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100 mg		Get quote

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生物&药学活性

SB-435495 is a potent, orally active inhibitor of Lp-PLA2 with IC50 of 0.06 nM.
SB-435495 inhibits the enzyme in whole human plasma with IC50 of 3 nM; shows little interaction with other CYP450 enzymes (CYP450 IC50: 1A2>100 mM, 2C9>100 uM, 2C19>40 uM, 2D6=37 uM).
SB-435495 effectively suppresses BRB breakdown in streptozotocin-diabetic Brown Norway rats,.

物理化学性质&存储条件

分子量	720.832
分子式	C38H40F4N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1(4H)-Pyrimidineacetamide, N-[2-(diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-5-[(1-methyl-1H-pyrazol-4-yl)methyl]-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-

参考文献

1. Blackie JA, et al. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2603-6.

2. Canning P, et al. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7213-8.

3. Tyurin VA, et al. Cell Death Differ. 2014 May;21(5):825-35.

4. Jiang Z, et al. Respir Res. 2012 Nov 12;13:100.

SB-435495 (SB435495)

生物&药学活性

物理化学性质&存储条件

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SB-435495 (SB435495)

生物&药学活性

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