SB-431542 |CAS:301836-41-9 Probechem Biochemicals

Chemical Structure : SB-431542

CAS No.: 301836-41-9

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SB-431542 (SB 431542;SB431542)

货号: PC-42581Not For Human Use, Lab Use Only.

SB-431542 is a potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM.

规格	价格	库存
10 mg	￥980	In stock
25 mg	￥1480	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

SB-431542 is a potent, specific TGF-β type I receptor (ALK5) inhibitor with IC50 of 94 nM.
SB-431542 also substantially inhibits ALK4 and 7, but not other ALKs.
SB-431542 efficiently inhibits the ability of activated ALK4, ALK5, and ALK7 to phosphorylate Smad2.
SB-431542 is a selective inhibitor of endogenous activin and TGF-beta signaling but has no effect on BMP signaling, and has no effect on components of the ERK, JNK, or p38 MAP kinase pathways.

物理化学性质&存储条件

分子量	384.3875
分子式	C22H16N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 40 mg/mL; Ethanol: 11.17 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES	Benzamide, 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-

参考文献

1. Callahan JF, et al. J Med Chem. 2002 Feb 28;45(5):999-1001.

2. Inman GJ, et al. Mol Pharmacol. 2002 Jul;62(1):65-74.

3. Matsuyama S, et al. Cancer Res. 2003 Nov 15;63(22):7791-8.

4. Hjelmeland MD, et al. Mol Cancer Ther. 2004 Jun;3(6):737-45.

SB-431542 (SB 431542;SB431542)

生物&药学活性

物理化学性质&存储条件

参考文献

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SB-431542 (SB 431542;SB431542)

生物&药学活性

物理化学性质&存储条件

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