SB-3CT |CAS:292605-14-2 Probechem Biochemicals

Chemical Structure : SB-3CT

CAS No.: 292605-14-2

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SB-3CT (SB 3CT;SB3CT)

货号: PC-42999Not For Human Use, Lab Use Only.

SB-3CT is a potent, selective gelatinase inhibitor that dually inhibits MMP2/9 with Ki of 13.9 and 600 nM, display little to no affinity for MMP-3, 7 and 1 (Ki=15, 96 and 206 uM).

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25 mg	￥1880	In stock
50 mg	￥2980	In stock
100 mg		Get quote

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生物&药学活性

SB-3CT is a potent, selective gelatinase inhibitor that dually inhibits MMP2/9 with Ki of 13.9 and 600 nM, display little to no affinity for MMP-3, 7 and 1 (Ki=15, 96 and 206 uM).
SB-3CT also poorly inhibits the closely related zinc-dependent metalloprotease ADAM-17.
SB-3CT demonstrates antitumor activity in a mouse model of T-cell lymphoma and shows significant reduction in the growth and number of experimental liver metastases and to an increase in survival.
SB-3CT blocks MMP-9 activity, including MMP-9-mediated laminin cleavage, thus rescuing neurons from apoptosis in transient focal cerebral ischemia

物理化学性质&存储条件

分子量	306.3999
分子式	C15H14O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Thiirane, 2-[[(4-phenoxyphenyl)sulfonyl]methyl]-

参考文献

1. Krüger A, et al. Cancer Res. 2005 May 1;65(9):3523-6.

2. Brown S, et al. Potent and Selective Mechanism-Based Inhibition of Gelatinases. J. Am. Chem. Soc., 2000, 122 (28), pp 6799-6800.

3. Gu Z, et al. J Neurosci. 2005 Jul 6;25(27):6401-8.

4. Bonfil RD, et al. Int J Cancer. 2006 Jun 1;118(11):2721-6.

SB-3CT (SB 3CT;SB3CT)

生物&药学活性

物理化学性质&存储条件

参考文献

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SB-3CT (SB 3CT;SB3CT)

生物&药学活性

物理化学性质&存储条件

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