SB-357134 | 5-HT6 antagonist | Probechem Biochemicals

Chemical Structure : SB-357134

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SB-357134 (SB 357134, SB357134)

货号: PC-61178Not For Human Use, Lab Use Only.

SB-357134 is a potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes.

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生物&药学活性

SB-357134 is a potent, selective, orally active and CNS penetrant 5-HT6 receptor antagonist with pKi of 8.5, displays 1300-fold selectivity over other 13 5-HT receptor subtypes.
SB-357134 inhibits 5-HT-stimulated cAMP accumulation in with pA2 of 7.63.
SB-357134 enhances memory and learning following chronic administration in mice.

物理化学性质&存储条件

分子量	523.22
分子式	C17H18Br2FN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-(piperazin-1-yl)benzene-1-sulfonamide

参考文献

1. Bromidge SM, et al. Bioorg Med Chem Lett. 2001 Jan 8;11(1):55-8.

2. Stean TO, et al. Pharmacol Biochem Behav. 2002 Apr;71(4):645-54.

3. Marcos B, et al. Eur J Neurosci. 2006 Sep;24(5):1299-306.

4. Rogers DC, et al. Psychopharmacology (Berl). 2001 Nov;158(2):114-9.

SB-357134 (SB 357134, SB357134)

生物&药学活性

物理化学性质&存储条件

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SB-357134 (SB 357134, SB357134)

生物&药学活性

物理化学性质&存储条件

参考文献

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