SB-332235 | CXCR2 antagonist | Probechem Biochemicals

Chemical Structure : SB-332235

CAS No.: 276702-15-9

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SB-332235 (SB332235)

货号: PC-60622Not For Human Use, Lab Use Only.

SB332235 (SB-332235) is a potent, selective and competitive CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with pKi of 8.92.

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10 mg	￥4580	In stock
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生物&药学活性

SB332235 (SB-332235) is a potent, selective and competitive CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with pKi of 8.92.
SB332235 inhibits N-Ac-PGP- and CXCL1-induced neutrophil influx and the increased pulmonary tissue MPO levels in micelung tissue homogenates.
SB332235 effectively inhibits smoke-induced inflammatory and mucus hypersecretory changes in rat lung.
SB332235 also attenuates microglial inflammatory reactivity induced by Aβ1-42 intrahippocampal injection in animal model of Alzheimer’s disease.

物理化学性质&存储条件

分子量	410.66
分子式	C13H10Cl3N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxybenzenesulfonamide

参考文献

1. Braber S, et al. Eur J Pharmacol. 2011 Oct 15;668(3):443-9.

2. Ryu JK, et al. J Neuroinflammation. 2015 Aug 9;12:144.

3. Bizzarri C, et al. Pharmacol Ther. 2006 Oct;112(1):139-49.

4. Stevenson CS, et al. Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L514-22.

SB-332235 (SB332235)

生物&药学活性

物理化学性质&存储条件

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SB-332235 (SB332235)

生物&药学活性

物理化学性质&存储条件

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