SB-328437 | CCR3 antagonist | Probechem Biochemicals

Chemical Structure : SB-328437

CAS No.: 247580-43-4

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SB-328437 (SB328437)

货号: PC-20723Not For Human Use, Lab Use Only.

SB-328437 is a potent, selective non-peptide CC chemokine receptor-3 (CCR3) antagonist, inhibits 125I-eotaxin binding to human eosinophils with IC50 of 4.5 nM.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote
1 g		Get quote

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生物&药学活性

SB-328437 is a potent, selective non-peptide CC chemokine receptor-3 (CCR3) antagonist, inhibits 125I-eotaxin binding to human eosinophils with IC50 of 4.5 nM.
SB-328437 inhibits binding of 125I-MCP-4 to human eosinophils with IC50 value of 7 nM.
SB-328437 (30 uM) does not inhibit the binding of 125I-IL-8 to CHO-CXCR1 cell or CHO-CXCR2 cell membranes, 125I-SLC (CCL-21) to HEK-293-CCR7 membranes, or [3H]LTD4 to guinea pig lung membranes.
SB-328437 is 250-fold selective for CCR3 over the other 7-TM receptors tested.
SB-328437 is potent inhibitor of eotaxin- and MCP-4-induced Ca(2+) mobilization in RBL-2H3-CCR3 cells and eosinophils.

物理化学性质&存储条件

分子量	378.38
分子式	C21H18N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(OC)[C@@H](NC(C1=C2C=CC=CC2=CC=C1)=O)CC3=CC=C([N+]([O-])=O)C=C3

参考文献

1. White JR, et al. J Biol Chem. 2000 Nov 24;275(47):36626-31.

SB-328437 (SB328437)

生物&药学活性

物理化学性质&存储条件

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SB-328437 (SB328437)

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物理化学性质&存储条件

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