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首页-小分子抑制剂&激动剂-GPCR-5-HT Receptor-SB-258585
SB-258585

Chemical Structure : SB-258585

CAS No.: 209480-63-7

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SB-258585 (SB258585)

货号: PC-63485Not For Human Use, Lab Use Only.

SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SB-258585 is a potent, selective and orally active 5-HT6 receptor antagonist with Ki of 8.9 nM, >160-fold selectivity over other 5-HT receptor subtypes.
SB-258585 also is an inhibitor of HCV entry in liver-derived cell lines as well as primary hepatocytes.
SB-258585 modulates localization of the coreceptor tight junction protein claudin-1 (CLDN1) in a 5-HT6-independent manner, induces intracellular accumulation of CLDN1.

物理化学性质&存储条件

分子量 487.356
分子式 C18H22IN3O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-Iodo-N-[4-methoxy-3-(4-methyl-1-piperazinyl)phenyl]benzenesulfonamide

参考文献

1. Hirst WD, et al. Br J Pharmacol. 2000 Aug;130(7):1597-605.

2. Riva L, et al. J Virol. 2018 Apr 27;92(10). pii: e01982-17.

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