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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-SB-242235
SB-242235

Chemical Structure : SB-242235

CAS No.: 193746-75-7

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SB-242235 (SB 242235, SB242235)

货号: PC-45452Not For Human Use, Lab Use Only.

SB-242235 is a selective p38 MAPK inhibitor, inhibits IL-1 beta induction of p38 MAPK in primary human chondrocytes with IC50 of 1 uM.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SB-242235 is a selective p38 MAPK inhibitor, inhibits IL-1 beta induction of p38 MAPK in primary human chondrocytes with IC50 of 1 uM.
SB-242235 inhibits LPS-stimulated serum levels of TNFalpha in normal rats with mean ED50 of 3.99 mg/kg.

物理化学性质&存储条件

分子量 353.3934
分子式 C19H20FN5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 48 mg/mL
Chemical Name/SMILES

Pyrimidine, 4-[4-(4-fluorophenyl)-1-(4-piperidinyl)-1H-imidazol-5-yl]-2-methoxy-

参考文献

1. Badger AM, et al. Osteoarthritis Cartilage. 2000 Nov;8(6):434-43.

2. Badger AM, et al. Arthritis Rheum. 2000 Jan;43(1):175-83.

3. Ward KW, et al. Xenobiotica. 2002 Mar;32(3):221-33.

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