SAV13 | SaeR inhibitor | Probechem Biochemicals

Chemical Structure : SAV13

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SAV13 (SaeR inhibitor SAV13)

货号: PC-21137Not For Human Use, Lab Use Only.

SAV13 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 1.06 uM in luciferase assays, reduces expression of hla and other virulence factors.

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SAV13 is a selective small molecule inhibitor of S. aureus exoprotein expression regulator (SaeR) withEC50 of 1.06 uM in luciferase assays, reduces expression of hla and other virulence factors.
SAV13 interacts with the amino acid E159 of SaeR protein.
SAV13 inhibits hla expression in the USA300 strain with EC50 around 3 µM, and 10 µM in the agrA deletion mutant, while around 80 µM in saeR or saeS deletion strains.
SAV13 supresses S. aureus pathogenesis by inhibiting the expression of virulence factors without any killing effect.
SAV13 demonstrates in vivo effectiveness against S. aureus infection in mice.

物理化学性质&存储条件

分子量	423.22
分子式	C19H13Cl2FN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[[3,5-Dichloro-4-[(4-fluorophenyl)methoxy]phenyl]methylene]-1-methyl-2,4,6(1H,3H,5H)-pyrimidinetrione

参考文献

1. Peng Gao, et al. Emerg Microbes Infect. 2023 Sep 6;2254415.

SAV13 (SaeR inhibitor SAV13)

生物&药学活性

物理化学性质&存储条件

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SAV13 (SaeR inhibitor SAV13)

生物&药学活性

物理化学性质&存储条件

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