SARS-CoV-2 nsp14 inhibitor 25

Chemical Structure : SARS-CoV-2 nsp14 inhibitor 25

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货号: PC-38498Not For Human Use, Lab Use Only.

SARS-CoV-2 nsp14 inhibitor 25 is a highly potent, selective, nucleoside-derived inhibitor of SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) with IC50 of 19 nM, no inhibition against human RNA N7-MTase (hRNMT, IC50>50 uM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SARS-CoV-2 nsp14 inhibitor 25 is a highly potent, selective, nucleoside-derived inhibitor of SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) with IC50 of 19 nM, no inhibition against human RNA N7-MTase (hRNMT, IC50>50 uM).
SARS-CoV-2 nsp14 N7-MTase catalyzes the transfer of the methyl group from the S-adenosyl-l-methionine (SAM) cofactor to the N7-guanosine cap, which is essential for the stability of viral RNA, translation of mRNAs, and virus evasion from innate immunity.

物理化学性质&存储条件

分子量	489.507
分子式	C20H23N7O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)-3-cyano-N-ethyl-4-methoxybenzenesulfonamide

参考文献

1. Rostom Ahmed-Belkacem, et al. J Med Chem. 2022.