SARS-CoV-2 nsp12 NiRAN domain inhibitor NCI-2 | nsp12 NiRAN domain inhibitor

Chemical Structure : SARS-CoV-2 nsp12 NiRAN domain inhibitor NCI-2

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SARS-CoV-2 nsp12 NiRAN domain inhibitor NCI-2 (SW090466, NiRAN covalent inhibitor 2)

货号: PC-23595Not For Human Use, Lab Use Only.

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生物&药学活性

NCI-2 is a small molecule inhibitor of SARS-CoV-2 nsp12 NiRAN domain, covalently binds to an active site cysteine (Cys53) in the NiRAN domain, inhibiting nsp12-dependent AMPylation of nsp9 with IC50 of 4.3 uM.
NCI-2 can enter cells, bind to, and inactivate ectopically expressed nsp12.
NCI-2 shows inhibition of NiRAN-dependent RNAylation of nsp9 and an increase in the thermal stability of nsp12.
NCI-2 demonstrates limited potency in inhibiting SARS-CoV-2 replication (IC50=200 uM).

物理化学性质&存储条件

分子量	240.64
分子式	C10H9ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 5-(chloromethyl)-7-hydroxypyrazolo[1,5-a]pyridine-3-carboxylate

参考文献

1. Hernandez G, et al. bioRxiv [Preprint]. 2024 Nov 25:2024.11.22.624893.

SARS-CoV-2 nsp12 NiRAN domain inhibitor NCI-2 (SW090466, NiRAN covalent inhibitor 2)

生物&药学活性

物理化学性质&存储条件

参考文献

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SARS-CoV-2 nsp12 NiRAN domain inhibitor NCI-2 (SW090466, NiRAN covalent inhibitor 2)

生物&药学活性

物理化学性质&存储条件

参考文献

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