SARS-CoV-2 PLpro inhibitor 7 is a potent, selective and covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 94 nM, shows SARS-CoV-2 antiviral activity with EC50 of 1.1 uM.
SARS-CoV-2 PLpro inhibitor 7 is a potent, selective and covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 94 nM, shows SARS-CoV-2 antiviral activity with EC50 of 1.1 uM.
SARS-CoV-2 PLpro inhibitor 7 engages in a hydrogen bond with Trp106 of PLpro.
SARS-CoV-2 PLpro inhibitor 7 inhibits PLpro-mediated peptide cleavage, ubiquitin cleavage, and ISG15 cleavage, has antiviral activity against SARS-CoV-2 and lack cytotoxicity in Vero E6 cells.
SARS-CoV-2 PLpro inhibitor 7 deoes not inhibit a representative panel of human DUBs.
SARS-CoV-2 PLpro inhibitor 7 inhibits PLpro with Ub-rhodamine and ISG15 substrates with IC50 values of 76 and 39 nM, respectively.
