Chemical Structure : SARS-CoV-2 Mpro inhibitor 18
CAS No.:
2883677-93-6
SARS-CoV-2 Mpro inhibitor 18
货号: PC-25310Not For Human Use, Lab Use Only.
SARS-CoV-2 Mpro inhibitor 18 is potent, reversible covalent inhibitor of SARS-CoV-2 Mpro with IC50 of 8 nM, inhibits virus induced cytopathic effect (CPE) with EC50 of 58 nM.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
SARS-CoV-2 Mpro inhibitor 18 is potent, reversible covalent inhibitor of SARS-CoV-2 Mpro with IC50 of 8 nM, inhibits virus induced cytopathic effect (CPE) with EC50 of 58 nM.
SARS-CoV-2 Mpro inhibitor 18 has 10-fold weaker inhibition of MERS Mpro compared to SARS-CoV Mpro, inhibits HCoV-229E Mpro with IC50 of 10 nM.
SARS-CoV-2 Mpro inhibitor 18 exhibits similar EC50 values across the USA-WA1/2020, alpha, beta, delta, and omicron variants (IC50<100 nM)
SARS-CoV-2 Mpro inhibitor 18 is also active against the alpha coronavirus HCoV-229E (EC50 = 0.15 μM), beta coronavirus HCoV-OC43 (EC50 = 0.15 μM), and MERS-CoV (EC50 = 0.058 μM).
SARS-CoV-2 Mpro inhibitor 18 (300 and 600 mg/kg/d, oral) significantly reduced lung virus titers, exhibited in vivo efficacy against SARS-CoV-2 MA10 infection in mice.
物理化学性质&存储条件
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分子量
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601.79
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分子式
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C32H51N5O6
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-3-((S)-3-Cyclobutyl-2-((R)-2-cyclopentyl-N-methyl-2-pivalamidoacetamido)propanamido)-N-cyclopropyl-2-oxo-4-((S)-2-oxopiperidin-3-yl)butanamide
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参考文献
1. Tan QW, et al. J Med Chem. 2025 Aug 7. doi: 10.1021/acs.jmedchem.5c00581.
