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SARM1 inhibitor NB-7

Chemical Structure : SARM1 inhibitor NB-7

CAS No.: 2665712-31-0

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SARM1 inhibitor NB-7 (NB7)

货号: PC-24261Not For Human Use, Lab Use Only.

SARM1 inhibitor NB-7 is a potent, selective and uncompetitive inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 with biochemical IC50 of 0.025 uM, and IC50 of 0.008 uM in SARM-induced cell-death rescue assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SARM1 inhibitor NB-7 is a potent, selective and uncompetitive inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 with biochemical IC50 of 0.025 uM, and IC50 of 0.008 uM in SARM-induced cell-death rescue assays.
NB-7 potently protectes against axon degeneration with IC50 of 0.11 uM in cellular models of nerve injury.

物理化学性质&存储条件

分子量 340.81
分子式 C18H17ClN4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-(4-chlorophenyl)-N-(4-methyl-3-(pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

参考文献

1. Matthew Bratkowski, et al. Neuron. 2022 Nov 16;110(22):3711-3726.e16.

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