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SARM1 inhibitor NB-3

Chemical Structure : SARM1 inhibitor NB-3

CAS No.:

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SARM1 inhibitor NB-3 (NB3)

货号: PC-49319Not For Human Use, Lab Use Only.

SARM1 inhibitor NB-3 is a potent, selective and uncompetitive inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 with biochemical IC50 of 0.195 uM, and IC50 of 0.08 uM in SARM-induced cell-death rescue assays.

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纯度 & COA & 质检文件 纯度: 99.7% (HPLC) Select Batch:

生物&药学活性

SARM1 inhibitor NB-3 is a potent, selective and uncompetitive inhibitor of the nicotinamide adenine dinucleotide (NAD) hydrolase SARM1 with biochemical IC50 of 0.195 uM, and IC50 of 0.08 uM in SARM-induced cell-death rescue assays.
SARM1 inhibitor NB-3 targets the NAD-dependent active-site by intercepting NAD hydrolysis and undergoing covalent conjugation with the reaction product adenosine diphosphate ribose (ADPR).
SARM1 inhibitor NB-3 is highly potent and confer compelling neuroprotection in preclinical models of neurological injury and disease.
NB-3 does not inhibit the most closely related NAD hydrolase, CD38, and a panel of Sirtuins and PARPs (IC50 > 50 μM)
NB-3 lowers plasma NfL and improves functional outcomes in preclinical models of nerve injury and neuropathy.
NB-3 attenuates neurodegeneration decline in preclinical models of chemotherapy-induced peripheral neuropathy (CIPN).

物理化学性质&存储条件

分子量 261.248
分子式 C11H14F3N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-1-methyl-1-(1-(pyridin-4-yl)ethyl)-3-(2,2,2-trifluoroethyl)urea

参考文献

1. Matthew Bratkowski, et al. Neuron. 2022 Nov 16;110(22):3711-3726.e16.

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