SARM1 inhibitor 7

Chemical Structure : SARM1 inhibitor 7

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货号: PC-24260Not For Human Use, Lab Use Only.

SARM1 inhibitor 7 is a potent, selective sterile alpha and TIR Motif Containing 1 (SARM1) inhibitor with biochemical IC50 of 0.3 uM (hSARM1).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

SARM1 inhibitor 7 is a potent, selective sterile alpha and TIR Motif Containing 1 (SARM1) inhibitor with biochemical IC50 of 0.3 uM (hSARM1).
SARM1 inhibitor 7 blocks vacor-induced neurite degeneration in iMotor neurons.
SARM1 inhibitor 7 is selective against a selection of NADases such as CD38 and CD157, and a panel of closely related enzymes.
SARM1 inhibitor 7 (50 mg/kg) showed efficacy in mouse SNI model following oral administration.

物理化学性质&存储条件

分子量	285.29
分子式	C13H17F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[(3R)-4,4-difluorotetrahydrofuran-3-yl]-1-methyl-1-[(1S)-1-(4-pyridyl)ethyl]urea

参考文献

1. Giroud M, et al. J Med Chem. 2025 Mar 18. doi: 10.1021/acs.jmedchem.4c03127.