SARM1 inhibitor 19

Chemical Structure : SARM1 inhibitor 19

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货号: PC-26502Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

SARM1 inhibitor 19 is a potent, selective and orally bioavailable SARM1 inhibitor with pIC50 of 7.1 (hSARM1), protect primary rat and mouse DRGs treated with vincristine with EC50 of 55 nM and 113 nM respectively.
SARM1 inhibitor 19 binds at the interfaces of neighboring TIR subunits in the double-stranded assembly traps the enzyme in a state poised for activity while blocking the active sites.
SARM1 inhibitor 19 exacerbates neuronal degeneration and cell death in vitro.
SARM1 inhibitor 19 exhibits dose-dependent efficacy and subinhibitory effect in a mouse SNI model.

物理化学性质&存储条件

分子量	454.51
分子式	C25H23FN8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(7-((2-(Dimethylamino)ethyl)amino)-1-methyl-2-(pyridin-4-yl)-1H-imidazo[4,5-c]pyridin-6-yl)-6-fluoro-1H-indole-4-carbonitrile

参考文献

1. Albanese SK, et al. J Med Chem. 2026 Apr 8. doi: 10.1021/acs.jmedchem.6c00352.