SAR7334 | TRPC6 inhibitor | Probechem Biochemicals

Chemical Structure : SAR7334

CAS No.: 1333210-07-3

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SAR7334 (SAR-7334, SAR 7334)

货号: PC-20743Not For Human Use, Lab Use Only.

SAR7334 (SAR-7334 ) is a highly potent and selective inhibitor of TRPC6 channel, reduces TRPC6-mediated Ca2+ influx with IC50 of 9.5 nM.

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10 mg	￥2480	In stock
50 mg	￥5280	In stock
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生物&药学活性

SAR7334 (SAR-7334 ) is a highly potent and selective inhibitor of TRPC6 channel, reduces TRPC6-mediated Ca2+ influx with IC50 of 9.5 nM.
SAR7334 also inhibits TRPC3 and TRPC7 channels at significantly higher concentrations (IC50=282 nM and 226 nM respectively), has no appreciable effects on TRPC4 or TRPC5 channels (IC50>10 uM).
SAR7334 dose-dependently reduces TRPC6 currents in patch-clamp experiments on TRPC6-HEK-FITR cells with IC50 of 7.9 nM.
SAR7334 suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice, does not change mean arterial pressure in spontaneously hypertensive rats (SHR).

物理化学性质&存储条件

分子量	367.88
分子式	C21H22ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((1R,2R)-2-((R)-3-aminopiperidin-1-yl)-2,3-dihydro-1H-inden-1-yl)oxy)-3-chlorobenzonitrile

参考文献

1. Maier T, et al. Br J Pharmacol. 2015 Jul;172(14):3650-60.

2. Chauvet S, et al. Front Pharmacol. 2016 Dec 12;7:486.

SAR7334 (SAR-7334, SAR 7334)

生物&药学活性

物理化学性质&存储条件

参考文献

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SAR7334 (SAR-7334, SAR 7334)

生物&药学活性

物理化学性质&存储条件

参考文献

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