SAR439883 | PKR inhibitor | Probechem Biochemicals

Chemical Structure : SAR439883

加入收藏

SAR439883 (SAR 439883)

货号: PC-72066Not For Human Use, Lab Use Only.

SAR439883 (SAR 439883) is a novel potent, selective, orally active PKR inhibitor with IC50 of 0.68/0.69 uM against hPKR/mPKR, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SAR439883 (SAR 439883) is a novel potent, selective, orally active PKR inhibitor with IC50 of 0.68/0.69 uM against hPKR/mPKR, respectively.
SAR439883 dose-dependently ameliorated the AβO-induced cognitive impairment in both Y-maze and Morris Water Maze, prevented loss of synaptic proteins, and reduced levels of the proinflammatory cytokine interleukin-1β In both mouse models.
SAR439883 rescued memory deficits and prevented neurodegeneration in animal models of AD-like pathology, suggesting that inhibition of PKR is a potential therapeutic approach for AD.

物理化学性质&存储条件

分子量	384.852
分子式	C19H23ClF2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-chloro-5-(((3R,5R,6R,8R)-3,6-difluoro-1-azaspiro[4.5]decan-8-yl)oxy)-3,3-dimethylisoindolin-1-one

参考文献

1. Matilde Lopez-Grancha, et al. J Pharmacol Exp Ther. 2021 Sep;378(3):262-275.

SAR439883 (SAR 439883)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SAR439883 (SAR 439883)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.