SAR296968 | NCX inhibitor | Probechem Biochemicals

Chemical Structure : SAR296968

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SAR296968 (SAR 296968)

货号: PC-72108Not For Human Use, Lab Use Only.

SAR296968 (SAR 296968) is a potent, selective Na+/Ca2+ exchanger (NCX) inhibitor, potently inhibits hNCX1/2/3 with IC50 of 74/23/129 nM, respectively.

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生物&药学活性

SAR296968 (SAR 296968) is a potent, selective Na+/Ca2+ exchanger (NCX) inhibitor, potently inhibits hNCX1/2/3 with IC50 of 74/23/129 nM, respectively.
SAR296968 showed the same range of inhibitory potency on NCX1 orthologs from dog, guinea pig, pig, rabbit, and rat (IC50=20-200 nM).
SAR296968 inhibited both the forward and reverse mode of the NCX current in a concentration-dependent manner with similarly high potency in voltage-clamp studies in guinea pig cardiomyocytes.
SAR296968 displays little to no effect against 5-HT2B, benzodiazepine peripheral receptor, norepinephrine uptake, dopamine uptake, AR and PR.
SAR296968 exhibited antiarrhythmic properties in animal models of arrhythmias related to early or late afterdepolarizations, significantly increased left ventricular contractility in anesthetized pigs.

物理化学性质&存储条件

分子量	410.488
分子式	C22H22N2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (4.1 mg/mL)
Chemical Name/SMILES	2-[[(2S)-3,4-Dihydro-2-(2-methylphenyl)-2H-1-benzopyran-6-yl]oxy]-N-(2-hydroxyethyl)-5-thiazolecarboxamide

参考文献

1. Michel Pelat, et al. J Pharmacol Exp Ther. 2021 May;377(2):293-304.

SAR296968 (SAR 296968)

生物&药学活性

物理化学性质&存储条件

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SAR296968 (SAR 296968)

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物理化学性质&存储条件

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