SAR216471 hydrochloride | P2Y12 antagonist | Probechem Biochemicals

Chemical Structure : SAR216471 hydrochloride

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SAR216471 hydrochloride (SAR-216471 hydrochloride)

货号: PC-61535Not For Human Use, Lab Use Only.

SAR216471 hydrochloride is a potent, highly selective, intravenous and oral, reversible P2Y12 receptor antagonist with binding IC50 of 17 nM.

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生物&药学活性

SAR216471 hydrochloride is a potent, highly selective, intravenous and oral, reversible P2Y12 receptor antagonist with binding IC50 of 17 nM.
SAR216471 inhibits ADP-induced platelet aggregation in human platelet rich plasma with IC50 of 0.1 uM.
SAR216471 exhibits an ED50 of 2.75mg/kg in ex vivo platelet aggregation model in rats.

物理化学性质&存储条件

分子量	599.51
分子式	C28H31ClN8O3.HCl
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-(4-butyryl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl)-5-chloro-1-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)-1H-indole-3-carboxamide hydrochloride

参考文献

1. Boldron C, et al. J Med Chem. 2014 Sep 11;57(17):7293-316.

2. Delesque-Touchard N, et al. Thromb Res. 2014 Sep;134(3):693-703.

SAR216471 hydrochloride (SAR-216471 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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SAR216471 hydrochloride (SAR-216471 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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