SAR131675 | VEGFR3 inhibitor | Probechem Biochemicals

Chemical Structure : SAR131675

CAS No.: 1433953-83-3

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SAR131675 (SAR 131675 )

货号: PC-73181Not For Human Use, Lab Use Only.

SAR131675 is a potent and selective VEGFR3 inhibitor with IC50 of 23 nM.

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥2980	In stock
50 mg	￥4980	In stock
100 mg	￥7980	In stock
1 g		Get quote

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生物&药学活性

SAR131675 is a potent and selective VEGFR3 inhibitor with IC50 of 23 nM.
SAR131675 is highly selective for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases, and is moderately active on VEGFR-2.
SAR131675 inhibits VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells with IC50 values of 20 and 45 nM, respectively.
SAR131675 dose dependently inhibits the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD with IC50 of 20 nM.
SAR131675 significantly reduces lymph node invasion and lung metastasis, exhibits antilymphangiogenic activity in vivo, significantly reduces TAM infiltration and aggregation in 4T1 tumors.

物理化学性质&存储条件

分子量	358.39
分子式	C18H22N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
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Solubility
Chemical Name/SMILES

参考文献

1. Alam A, et al. Mol Cancer Ther. 2012 Aug;11(8):1637-49.

2. Hwang SD, et al. Cell Death Dis. 2019 Mar 4;10(3):219.

SAR131675 (SAR 131675 )

生物&药学活性

物理化学性质&存储条件

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SAR131675 (SAR 131675 )

生物&药学活性

物理化学性质&存储条件

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