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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-JAK-SAR-20347
SAR-20347

Chemical Structure : SAR-20347

CAS No.: 1450881-55-6

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SAR-20347 (SAR20347)

货号: PC-35842Not For Human Use, Lab Use Only.

SAR-20347 (SAR20347) is a potent, selective inhibitor of JAK1 and Tyk2 with IC50 of 59 and 13 nM in TR-FRET assays, shows selectivity against JAK2 and JAK3 (IC50>800 nM).

规格 价格 库存 数量
5 mg ￥1180 In stock
10 mg ￥1880 In stock
25 mg ￥3280 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SAR-20347 (SAR20347) is a potent, selective inhibitor of JAK1 and Tyk2 with IC50 of 59 and 13 nM in TR-FRET assays, shows selectivity against JAK2 and JAK3 (IC50>800 nM).
SAR-20347 potently inhibits IL-12-mediated STAT4 phosphorylation with IC50 of 126 nM.
SAR-20347 inhibits JAK1-mediated IL-6 pSTAT3 signaling with IC50 of 345 nM in TF-1 and 407 nM in CD4+ cells, poorly inhibits JAK2 mediated STAT5 phosphorylation with IC50 of >1 uM.
SAR-20347 ameliorates imiquimod-induced psoriasis-like dermatitis in vivo.

物理化学性质&存储条件

分子量 444.847
分子式 C21H18ClFN4O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-chloro-6-fluorophenyl)-5-((4-(morpholine-4-carbonyl)phenyl)amino)oxazole-4-carboxamide

参考文献

1. Works MG, et al. J Immunol. 2014 Oct 1;193(7):3278-87.

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