SAR-020106 |CAS:1184843-57-9 Probechem Biochemicals

Chemical Structure : SAR-020106

CAS No.: 1184843-57-9

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SAR-020106 (SAR-20106, SAR020106)

货号: PC-63043Not For Human Use, Lab Use Only.

SAR-020106 (SAR-20106) is a potent and selective CHK1 inhibitor with IC50 of 13 nM, with high selectivity over CHK2 (IC50>100 uM).

规格	价格	库存
5 mg	￥1180	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

SAR-020106 (SAR-20106) is a potent and selective CHK1 inhibitor with IC50 of 13 nM, with high selectivity over CHK2 (IC50>100 uM).
SAR-020106 inhibits HT29 cells with IC50 of 0.53 uM in SRB cytotoxicity assay.
SAR-020106 inhibits cytotoxic drug-induced autophosphorylation of CHK1 at S296 and blocks the phosphorylation of CDK1 at Y15 in a dose-dependent fashion both in vitro and in vivo.

物理化学性质&存储条件

分子量	382.852
分子式	C19H19ClN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-((8-chloroisoquinolin-3-yl)amino)-3-((1-(dimethylamino)propan-2-yl)oxy)pyrazine-2-carbonitrile

参考文献

1. Reader JC, et al. J Med Chem. 2011 Dec 22;54(24):8328-42.

2. Walton MI, et al. Mol Cancer Ther. 2010 Jan;9(1):89-100.

SAR-020106 (SAR-20106, SAR020106)

生物&药学活性

物理化学性质&存储条件

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SAR-020106 (SAR-20106, SAR020106)

生物&药学活性

物理化学性质&存储条件

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