SANT-1 |CAS:304909-07-7 Probechem Biochemicals

Chemical Structure : SANT-1

CAS No.: 304909-07-7

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SANT-1 (SANT1)

货号: PC-62171Not For Human Use, Lab Use Only.

SANT-1 is a potent, cell-permeable Smoothened inhibitor (Kd=1.2 nM) that inhibits Sonic hedgehog (Shh) signaling.

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25 mg	￥1880	In stock
50 mg	￥2880	In stock
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生物&药学活性

SANT-1 is a potent, cell-permeable Smoothened inhibitor (Kd=1.2 nM) that inhibits Sonic hedgehog (Shh) signaling.
SANT-1 inhibits smoothened agonist effects with an IC50 of 20 nM in Shh-LIGHT2 cells.
SANT-1 significantly reduces Gli1 gene expression, and reduces proliferation of glioma stem-like cells.

物理化学性质&存储条件

分子量	373.504
分子式	C23H27N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

参考文献

1. Chen JK, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.

2. Cohen JR, et al. BMC Cancer. 2010 Dec 9;10:676.

3. Dixit D, et al. Cancer Lett. 2013 Aug 19;336(2):347-58.

SANT-1 (SANT1)

生物&药学活性

物理化学性质&存储条件

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SANT-1 (SANT1)

生物&药学活性

物理化学性质&存储条件

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