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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HIV-SAMT-247
SAMT-247

Chemical Structure : SAMT-247

CAS No.: 850715-59-2

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SAMT-247 (SAMT247)

货号: PC-62191Not For Human Use, Lab Use Only.

SAMT-247 is a potent HIV-1 nucleocapsid protein NCp7 inhibitor with EC50 of 0.6 uM with low cellular toxicity (TC50>100 uM) in cultured and primary cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SAMT-247 is a potent HIV-1 nucleocapsid protein NCp7 inhibitor with EC50 of 0.6 uM with low cellular toxicity (TC50>100 uM) in cultured and primary cells.
    SAMT-247 promotes covalent acetylation of Gag intracellularly, thereby blocking Gag processing and reducing infectivity.

    物理化学性质&存储条件

    分子量 266.32
    分子式 C12H14N2O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Ethanethioic acid,S-[2-[[(3-amino-3-oxopropyl)amino]carbonyl]phenyl] ester

    参考文献

    1. Miller Jenkins LM, et al. Nat Chem Biol. 2010 Dec;6(12):887-9.

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