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首页-小分子抑制剂&激动剂-Others-Other Targets-SAM486A
SAM486A

Chemical Structure : SAM486A

CAS No.: 149400-88-4

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SAM486A (Sardomozide, CGP 48664)

货号: PC-24844Not For Human Use, Lab Use Only.

SAM486A (Sardomozide) is a highly potent, selective S-adenosylmethionine decarboxylase (SAMDC) inhibitor with IC50 of 5 nM, inhibits intracellular spermidine and spermine pools.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SAM486A (Sardomozide) is a highly potent, selective S-adenosylmethionine decarboxylase (SAMDC) inhibitor with IC50 of 5 nM, inhibits intracellular spermidine and spermine pools.
SAM486A (Sardomozide) shows a pronounced antiproliferative activity (IC50 of 0.71 uM, human T24 bladder carcinoma cells).
SAM486A (Sardomozide) displays >2500-fold selective over diamine oxidase (DAO).

物理化学性质&存储条件

分子量 230.28
分子式 C11H14N6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(4-Carbamimidoyl-2,3-dihydro-1H-inden-1-ylidene)hydrazine-1-carboximidamide

参考文献

1. Stanek J, et al. J Med Chem. 1993 Jul 23;36(15):2168-71.

2. Regenass U, et al. Cancer Res. 1994 Jun 15;54(12):3210-7.

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