SAIT-PDZ-5179 | GIPC1 inhibitor | Probechem Biochemicals

Chemical Structure : SAIT-PDZ-5179

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SAIT-PDZ-5179 (GIPCi)

货号: PC-27524Not For Human Use, Lab Use Only.

SAIT-PDZ-5179 is a small molecule inhibitor of GAIP-interacting protein C terminus 1 (GIPC1), selectively target the PDZ domain of GIPC1 with ITC KD of 943 nM.

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生物&药学活性

SAIT-PDZ-5179 is a small molecule inhibitor of GAIP-interacting protein C terminus 1 (GIPC1), selectively target the PDZ domain of GIPC1 with ITC KD of 943 nM.
SAIT-PDZ-5179 attenuates downstream signaling pathways in PDAC cells, leading to suppression of multiple downstream targets.
SAIT-PDZ-5179 induces a modest cytotoxic response in PDAC and patient-derived PDX cell lines.
SAIT-PDZ-5179 markedly reduces colony formation in PANC-1, KPC, AsPC-1, PANC-02, PDX-6741 and PDX-7114 cells.
SAIT-PDZ-5179 (10 mg/kg, twice weekly) exhibits significant antitumor activity in a syngeneic orthotopic murine model of PDAC.
SAIT-PDZ-5179 induces remodeling of immune and extracellular matrix-associated pathways in PDAC tumors.

物理化学性质&存储条件

分子量	507.52
分子式	C30H22FN3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl (Z)-(2-fluoro-5-(3-(9-hydroxyacridin-4-yl)-3-phenylacrylamido)phenyl)carbamate

参考文献

1. Rachamala HK, et al. Cell Rep. 2026 Jul 31:117777.

SAIT-PDZ-5179 (GIPCi)

生物&药学活性

物理化学性质&存储条件

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SAIT-PDZ-5179 (GIPCi)

生物&药学活性

物理化学性质&存储条件

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