SAG-524 | HBV inhibitor | Probechem Biochemicals

Chemical Structure : SAG-524

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SAG-524 (SAG524)

货号: PC-21756Not For Human Use, Lab Use Only.

SAG-524 (SAG524) is a potent and orally bioavailable small molecule inhibitor of HBV replication, reduces HBsAg and HBV-DNA (IC50 = 0.92 nM and 1.4 nM) by destabilizing HBV-RNA.

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生物&药学活性

SAG-524 (SAG524) is a potent and orally bioavailable small molecule inhibitor of HBV replication, reduces HBsAg and HBV-DNA (IC50 = 0.92 nM and 1.4 nM) by destabilizing HBV-RNA.
SAG-524 selectively destabilizes HBV-RNA via PAPD5, but not GAPDH or albumin mRNA, by shortening the poly(A) tail.
SAG-524 produces potent reductions of serum HBsAg and HBcrAg, and the minimum effective dose of 6 mg/kg/day in HBV-infected PXB mice.
SAG-524 greatly reduces HBsAg and cccDNA in the liver due to reduction of human hepatocytes with good tolerability, when combined with entecavir.

物理化学性质&存储条件

分子量	594.13
分子式	C30H32ClN5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(3-chloro-4-(pyrrolidin-1-yl)phenyl)-1-(2-(4-(2-methoxyethyl)piperazin-1-yl)benzo[d]thiazol-6-yl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

参考文献

1. Watanabe T, et al. J Gastroenterol. 2024 Feb 5. doi: 10.1007/s00535-023-02070-y.

SAG-524 (SAG524)

生物&药学活性

物理化学性质&存储条件

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SAG-524 (SAG524)

生物&药学活性

物理化学性质&存储条件

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